The purpose of this proposal is for support of a children's cancer treatment center at the Indiana University Medical Center. The general goals are (1) improved patient care through collaborative treatment protocols formulated by Children's Cancer Study Group A (CCSGA), (2) rapid assessment of new treatment protocols for children with malignancy through the combined efforts of CCSGA, (3) improved awareness and education of the medical center community and the state-wide medical community in the diagnosis and management of childhood malignancies.